The workaround is to configure the endpoint with the CacheManager using and the right classloader. For example: public final class XmlCacheManagerBuilder { private static CacheManager cacheManager; public static CacheManager createCacheManager() { ClassLoader cl = Thread .currentThread().getContextClassLoader(); try { URL url = XmlCacheManagerBuilder. class. getResource( "/ehcache-config.xml" ); Thread .currentThread().setContextClassLoader(CacheManager. class. getClassLoader()); XmlConfiguration xmlConfiguration = new XmlConfiguration(url); cacheManager = CacheManagerBuilder.newCacheManager((Configuration)xmlConfiguration); cacheManager.init(); } finally { Thread .currentThread().setContextClassLoader(cl); } return cacheManager; } public static CacheManager getCacheManager() { return cacheManager; } } <?xml version= "1.0" encoding= "UTF-8" ?> <blueprint xmlns= "http://www.osgi.org/xmlns/blueprint/v1.0.0" xsi:schemaLocation= " http://www.osgi.org/xmlns/blueprint/v1.0.0 http://www.osgi.org/xmlns/blueprint/v1.0.0/blueprint.xsd http://camel.apache.org/schema/spring http://camel.apache.org/schema/spring/camel-spring.xsd" xmlns:xsi = "http://www.w3.org/2001/XMLSchema-instance" > <bean id= "cacheManager" class= "org.jboss.qe.camel.components.ehcache.XmlCacheManagerBuilder" factory-method= "createCacheManager" /> <camelContext xmlns= "http://camel.apache.org/schema/blueprint" id= "ehcache" > <route> <from uri= "direct:start" /> <to uri= "ehcache://mycache?cacheManager=#cacheManager" /> <to uri= "log:org.apache.camel.component.ehcache?level=INFO&amp;showAll=true&amp;multiline=true" /> <to uri= "mock:result" /> </route> </camelContext> </blueprint>